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Using sacrifice rooms to get key pieces is better for not having to go out of your way for often weaker Angel Deals.
Try to hang on to a perthro rune or dice shard for right when you enter hush's chambers so you can reroll those treasure chest items or treasure room items.
Also, save all your Joker cards for AFTER you beat the boss, if a devil room opens up great, if it doesn't, then use your Joker card.
Nothing sucks more than getting a good run with the lost, going all the way to mega satan, owning him and then getting no portal.