Keeper run advice

[THRILLHO]

So I'm about to start up my Keeper runs. Every other character is 100%ed, but Keeper is completely untouched. Is there any obvious advice I should consider before starting? Any route best to focus on first for unlocks etc? Good/terrible synergies?

[SalmonSnake]

Kill Isaac ASAP to unlock wooden nickel as a starting item. Swallowed penny is probably the best trinket to have and like Lost, you want to get holy mantle

[CapnSquiggles]

So swallowed penny and piggy bank together basically guarantee you at least one coin when hit. The blindfold trinket(if you get to swallow the swallowed penny or smelt it) gives you more time to get coins after hit as the regular blinking period is often not enough to get to a coin in high pressure situations. Wooden nickle is important so you likely want to keep it and aim for all battery items. Double activate is especially great and the Habit will top off your chances at producing more coins.

The only thing I ever replace the wooden nickle with is if I have the habit, 9 volt and see the dull razor. You basically get to be invincible with it and if you have a hit produce coin effect or an orbital you can just march through the whole game.

Attack speed and damage are important for him but the most is just getting the ability to produce enough coins for life. You want to smash as many pots as you can in the basement to try and get the swallowed penny.

[Mediocre Melvin]

Dont play with him, hes awful and for dumb people, Im not dumb, my mom said Im smart