Any Tips for the Guardian Challenge?

[SlimeBucket64]

I keep making it to the last floor, but the AI for the Scapegoat keeps walking into Red Piles of Poop and Spikes, which keeps making me fail by loosing too much health to survive the last boss. Any suggestions would help.

[Washing Machine]

Luck. There's rooms/bosses where you are just going to have to accept that you take tons of damage.

Damage upgrades to kill the noise fast ofc helps alot, try to gain any means of healing alot (pill dupe / card mimic, something). I got super lucky and got Guppy's Paw at womb1 so could finish it with that. Bombing your way out of nonsense rooms (hands from ceiling in particular) helps a ton.

[Mooglethyst]

Do whatever you can to make the run as short as possible. We Need to Go Deeper and Emperor cards should be treasured.

[Amelouth]

It has been a long time since I did it, but I found a strategy in the wiki that looks good. You should give it a read:

https://bindingofisaacrebirth.gamepedia.com/The_Guardian

[urethra straw]

Honestly this may be the least well thought out of all the challenge. because there are some instances where you are guaranteed to die. They should have made it to where you could somehow control the punching bag or make give you the item that pushes enemies away(forgot what it was called) Because good luck beating mom or mom's heart without the bible.

[Justice]

hp restoring items like yum heart, nail, satanic bible, book of revelations
Always hold on cards that restore your hp
wiggle your spear for best damage
Don't take size down pills. You need bigger character hitbox to block enemy tears
DON'T TAKE DEVIL DEALS. You need hp more than damage

[usa60527]

Originally posted by Justice:

DON'T TAKE DEVIL DEALS. You need hp more than damage

You say this, but my first DD had guppy's paw and dead cat. You know a challenge may be flawed when this barely won me the game; if it weren't for lust dropping poison touch on Utero II, I would of thrown the run to Chub's maggot spam B.S in the very next room.

[Justice]

Originally posted by usa60527:

Originally posted by Justice:

DON'T TAKE DEVIL DEALS. You need hp more than damage

You say this, but my first DD had guppy's paw and dead cat. You know a challenge may be flawed when this barely won me the game; if it weren't for lust dropping poison touch on Utero II, I would of thrown the run to Chub's maggot spam B.S in the very next room.

It's a big Rng gamble and risk. Unless you had lots of hp or have alternative methods to restore hp, it's not advisable taking Devil deals in Guardian challenge. When I do this challenge: I relly on safe play and skill.
This is one of challenges, where you have to accept you're going to take damage (no matter how good you're in this game).