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The razor in apple might be tooth shot.
Polydactyly and belly Button can have their raison d`whatever understood through the simple fact that their item pool lacks such items/have actually neigh
Glaucoma, the Apple and Glass Shard along with their counterparts also have effects that are rather rare now or rather have already been.
Since it just one item.
Poison is the most common and arguably weakest status effect which becomes close to void on later floora.
Fear, quite common in comparison
Charm is quite rare but still has more sources, especially two ball of bandages will be aquired fairly often , especially with just Afterbirth though arguably, despite being a common item, Betrayal is rarely taken.
For Daze, there just have been the Bar and the Bombs which may be spawned by Afterbirth's #2, which kills more runs than it saves or the new Grey Poop.
There was literary just Tough Love for the "Critical Hit"
About a worse Anemic, well...in this case the effect may not really be wished for but having just an item dilute the pool to have bad items.