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Make sure you pick up some good items on the way, as the items you start out with will slowly get taken away from you as you go "up".
Pick up devil deals as much as you can; you lose red heart containers each floor, but not soul/black hearts. Again, unless they changed this.
Maybe that will work with other bosses as well, iunno.
Started out with Ipecac, Tech X and Quad Shot (and a couple more items including Guppy's Collar). Ipecac was the first to go after I went back up to Sheol, though.
But I did pick up some nifty items in the Devil Rooms along the way (mostly Guppy and the Locust of Pestilence trinket), all the while holding Guppy's head as my active item (which I got in a chest in the Dark Room after I accidentally used what appeared to be a telepill.
:D Yay
QFT
First started with bobby bombs, mascara, dr.fetus and scissors trinket. Thought thats neat loadout for challange (allmost made it through MS)... Second run - godhead +experimental treat - cant kill mini sins he spawns :)
(chain restart)