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I guess I should just set aside 3 hours one day and just power my way through it... Sigh.
No damage ups, no speed ups, and CONSTANTLY giving me the tankiest enemies imaginable (A room filled with infamy masks and those spiders that are super tanky that shoot ghost hairballs pretty much alternating every door in the Depths) and a MASSIVE Caves 1 where I took all the wrong turns under the curse that removes the map.
Simply because I was lucky enough and patient enough to get cupids arrow, then continuum and was graced by a 7 cent nuns habbit.
Sadly I never get that lucky playing the other challenges, despite the game treating me the same way
Head Trauma: Tiny Planet causes your tears to converge the fastest behind you, so try shooting in the opposite direction from the enemy for better aiming.
Solar System: Take your time, don't be afraid to hide on a rock or something while you wait for flies to come back around to where the enemy is. This one takes a lot of practice to get a feel for how you need to move.
Suicide King: Move forward while you shoot; the added forward momentum will cause your Ipecac shots to fly much faster and farther. NEVER shoot unless you're almost positive you'll hit something, so you won't have to worry about My Reflection as much.
Cat Got Your Tongue: It might be easier to try and get enemies to follow closely behind you and run into your hairball, rather than actively swinging it into enemies. Familiars that shoot bullets will also spawn blue flies from Guppy, so use those to your advantage. This one definitely gave me a ton of trouble; keep at it.
Beans!: Bomb out of rooms whenever you can, rather than waste additional bombs trying to hurt enemies.
Speed!: SCREW this challenge. Seriously. I don't even remember how I beat it. Insanely broken run, I guess. We Need To Go Deeper helps.
Blue Bomber: Again, bomb out of rooms.
Have a Heart: If you run into something that generates enemies, like a Mulligan, spend a while in that room refilling your health. Yeah, it takes forever, but it works.
BRAINS!: Really you just have to spend a lot of time getting a feel for how and when Bob's Brain fires. Make sure to spend the extra time in each room waiting for your brains to respawn before moving on.
Onan's Streak: Take your time lining up your shots. Fully charge your chocolate milk shots as much as possible, because destroying things in fewer hits means fewer chances to hurt yourself. Other than that this really boils down to getting gud at angling your shots.
Thank for for the tips Mooglegirl! I never even considered it before to get enemies to run INTO the hairball, instead of swinging it.
Although a note: When I played Beans! Today and failed miserably, I tried bombing out of rooms but the doors didn't break. A glitch, or maybe was that patched?
For BRAINS! I like to believe I'm honestly fairly good with Bob's Brain (At least better than Northernlion and Hutts seems to be) but I just can't handle some rooms (LIke void spawners that instantly spawn fast rushing units).. Any tips (besides being lucky to find sac-dag) on how to avoid being in the lose lose scenario of you shoot, you get hurt, you don't, you get hurt?
Now on flooded caves 1 with absolutely nothing to show for my progress besides +1 luck because every boss item has been health and item room not worth taking (my reflection and d7)
Solar system you'll want to focus on blue fly for normal enemies and red fly for bosses or enemies that move slowly or stay stationary, blue fly by default as a precaution however, stay hovered over rocks and use your flight to cheap enemies that can't fly, use blue fly for explosive enemies.
Speed advice would be find gold room and boss and go, look for the gold room on floors 1-4 at your own discretion and try to allow max 3 mins for depths 2, womb 1 and 2 and aim for under 2 mins for the first 4 floors, going by this you'll have a spare minute if you keep to it.
Onan's streak is a devil of a challenge it really is, it's incredibly generous however when you actually stop and target every enemy seperately, the most important factor is shoot when you're charged and avoid moving and shooting as in earlier levels you can only afford a couple misses before you die. Best advice would be to allow as much time as you need for this and only fire single charged shots for everything (as slow and painful as it is).
Brains! I will confess I haven't done it on steam as of yet but when I did it on ps4 the best advice would be to be near no enemies when you fire bobs brain, save all bombs for the womb/utero level or shoot enemies by doors to bypass tricky rooms. I have to forewarn you to save this challenge for last though because it goes all the way to the chest, yes it's horrible evil and the absolute worst, you're going to be hating this because no red hearts and only soul/black means no guaranteed recoveries from damage. Just get used to using bobs brain x3 and you'll get the hang of it little by little or you'll be a natural (hopefully) and you won't have as much trouble as I did, expect an update in the coming days as I've got 3 endings to get before I do this myself.
Suicide King is literally about momentum when firing a shot, you'll be darting part way to enemies and firing short of them (about half a room away). Honestly man the best advice I can offer on this is get good at running shots and don't go for quick or close kills as you'll be on ipecac, the absolute best run saving item is whip worm, you'll want it to shoot straight (or shot speed up) without much concern for it coming back.
Head trauma advice from me is fire in the opposite direction of the enemy and do small circles to let every tiny projectile whip past an enemy. Just think of it the same as using black powder to draw circles except around yourself, or you could try your own strategy but ideally moving yourself by enemies is the only way they catch most of your tears.
Beans! advice is fart on anything, save about 15 or 20 bombs for depths so you can skip right to mom (not moms heart thankfully), actually with 99 bombs if you use them only on champions and bosses you can pretty much bomb through both depths to her. Fair warning here if you encounter Brownie instant restart as he doesn't take poison damage and your butt bombs will heal him.
Have a heart, well tears up or damage up for an easier time, familiars are a real boon here so see lil' brim or brother bobby, that's doubling your damage output and you probably won't get full hp in this run honestly. Basically make the most of the empty hp by swapping it in for any devil deals you like, brimstone could make a run if you see it.
Blue bomber is literally mash kamikaze, with your bombs not able to harm you then you can safely plant mr mega bombs anywhere you'd like and kamikaze every small enemy with no concern, honestly not sure how this made your list.
I completely understand if you don't want to read this wall of text but my advice is centred on experience beating these specific challenges so I'd like to think it'll help someone in my shoes as these strategies are still working for me even now.
Blue Bomber made the list because absolutely everytime I try it I face enemies that are so tanky Kamikaze does little damage to them. (Champions upon champions. Black Death for example in a mini room so not only is it impossible to dodge, but he takes very little bomb damage)
I feel like the majority of the issues I'm facing is just simply the game trying its hardest to see me fail, and the devs having such oversights (Like the Brownie being invincible to you in Beans! for example) and leaving in rooms or enemies that are run ending because of your restrictions.
I beat the guardian, I beat Waka Waka, I beat Backasswards, and the Family Man, yet I can't beat When Life gives you Lemons or Have a Heart because the game just tries it's ♥♥♥♥♥♥♥♥ best to make me lose.
I just tried a few Have a Heart runs, and I had base stats (once again, running theme the entire day today.) except for my one good item, Holy Light, and I found Telekineses (forgot how to spell, 2 am and tired) and suddenly (I'm not even kidding) almost every single room had those ♥♥♥♥♥♥♥♥ floating heads that don't shoot anything (And Mama Mega which I popped didn't hurt them either).... LIke EVERYTHING I do is countered 100% by the game.. It's almost as if it's ♥♥♥♥♥♥ hardcoded to be a complete douche for some reason.
I NEVER have these issues on real runs.
Nothing aside from maintaining your spacing farther in advance, unfortunately. I did the challenge before Afterbirth came out, so I didn't have to put up with the portals. Holding into teleport cards you pick up might help, so you can use them to get out of especially perilous situations.
Well, yeah, because your normal runs don't have incredibly specific conditions about how you approach everything. Isaac inherently has a lot of RNG, so if bad runs are the only thing stopping you, the only thing to do is to keep trying.