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Cain isn't half bad either because the starting key, the paperclip (If you have it unlocked) is 1 less trinket in rotation which increases the odds you get a good trinket and you can open any golden chest free. Plus cain luck.
Maggy with her speed up pill can be "okay" if you hold R until the shop starts with a demon begger and she gets a good payout.
Eden depending on what he starts with can be "disgustingly good".
Lazurus can be okay because you can hold R until his start pill is a great one like tears up/i'm drowsey/ ect. And if plan C comes up and you haven't killed yourself yet, well.
But as a I learned somewhat recently, if you keep using the same characters, the greed machine will begin to jam a lot more frequently.
Also, Isaac has no flaws. Azazel has no range. Eve has crap for damage. Samson's only useful when he's hurting. Etc. With the D6, Isaac is all bonus and no penalty.
Edit: I'm blind as ♥♥♥♥
Lilith is just.... death. For EVERYTHING. Except maybe the Greed fight. There can be some challenge there depending.
Isaac lets you reroll stuff and can become god tier pretty fast.
Samson is just.... death. Much like Lilith. Get hit 3-4 times in a room, and then just don't leave until you clear it. Things MELT!
Lost can pretty much just hit the switch anytime and take a break. Giving you chances to leave, refresh mantle and try again.
Azazel actually isn't a great as in normal mode here: the greed and greedier fights are pretty nasty with him.
The rest are just meh in greed mode.
Also SASHIE: the same trinket can be seen more than once in a run. So starting with paper clip doesn't really help at all. Especially since gold chests are pretty rare here. :)
Lillith would be more of the opposite - you're unstoppable during regular floors, but the UG fight might be tricky.
Judas would be good choice, if you don't want or can't with any of the above, due to his Book of Belial potentially lasting for an entire floor.
We didn't forget. You didn't tell us. And we aren't mind readers and are too lazy to check your profile. :P