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Now, imo the lost with holy mantle unlocked is hard as hell still but fun, since you have free devil deals, spectral tears and flight. On the other hand... the keeper... *sigh*. Let's just say no one plays as the keeper for fun.
Meanwhile, the Keeper can not under any circumstances have any soul/black hearts which is terrible because his coin health acts like red hearts in which if he takes damage, his chances of getting a devil/angel deal are severely screwed. His damage and triple shot is nice but the fire rate severely limits his ability to deal with groups of enemies. And that .80 speed isn't doing him any favors. I know the gullet item which allows him more coins is a godsend but don't forget that this is one item out of a large chunk of all the items in the entire game. Your chances of getting it can be pretty damn slim and even smaller if you get Chaos.
Both of these characters have severe downsides but, in my opinion, the Keeper is much harder. Only two coin hearts for most runs unless you get the godsend that is Greed Gullet and if you get hit once, your devil/angel chances are down the toilet meanwhile the Lost has flight and spectral to make up for being very fragile and even the Holy Mantle which can also allow him to use curse rooms for free if you are careful while the Keeper, if not using any invincibility or teleports, is most likely dead if he even dares to enter a curse room.
when you have to specifically put "opinion" in your title, what has this world come to
Defence:
Both can only take two hits in a room, but if Lost only gets hit once, the Mantle comes back. That's basically infinite health for Lost, at one hit per room. If you're a Keeper without a coin tho, you're done, and the Wodden Nickel will fail three times in a row just to spite you. Sure Keeper can get the Mantle too, but he can't start with it and it's a very rare item.
Keeper is also slow for no reason, making dodging harder. Lost can fly, often making dodging way too easy.
That's 2 points for Lost so far, and Keeper's got nothing.
Offence:
Keeper has triple shot and a high damage multiplier, but his tear-rate sucks so some powerful items (Brimstone, Polyphemus, Inner Eye, etc.) will make it suck worse. Lost however, has flight and spectral tears, so you can often find a safe place where he can deal damage without taking damage.
Keeper wins this point, but Lost gets another point for defence. Lost however, has another advantage here...
Power-Up Availability:
Setting aside the obvious Gnawed Leaf thing, the Keeper basically needs to have the Swallowed Penny to survive (cuz' Piggy Bank ain't a sure-thing), and if you don't have enough bombs to bomb the right pots, welp, might as well restart. AB+ gives him Greeds Gullet, but it's such an insanely rare item, it might as well not be in the game. I unlocked it a day or two after release and I've only ever seen it once... when I wasn't the Keeper.
And Devil Deals? Forget about it. Even if you manage to avoid losing your deal to damage, unless your boss or item room has a health-up, no devil deals for you. Also, you can't have any of the two-heart ones, unless you have Judas' Tongue... but you still really need that Swallowed Penny tho... Oh, and Curse Rooms are basically off-limits.
So, yeah. No Guppy for Keeper. Really, nothing good for Keeper, ever.
Lost, on the other hand, gets free Devil Deals; the best odds of Devil Deals too, as long as you survive. Devil Items are some of the most powerful items in the game and most of them give you damage. Even with Curse of the Blind, you might as well just take the Deals anyway, because Lost has no health to lose. And as long as you can dodge some spiders, you get all the Curse Rooms you want.
Lost also turns Dead Cat from an iffy item into the best thing ever, making being Guppy too easy. Also, Leviathin, because why not?
Given how many OP things the Lost can get, I'm giving him 2 points for items and another point for offence too.
Fun:
Lost is stupidly OP, excepting his health. That makes him challenging, but also way too much fun. Keeper, excepting his damage, is completely useless, and is just a chore to play. The only thing Keeper does well is Greed Mode, but it's still not fun. If I want to play Greed, I'll play Lilith.
In Afterbirth, once I got my completion marks, I was done with Keeper forever, but I kept playing Lost when I felt like an adrenaline rush. Once I finally beat Delirium with Keeper, I'll be overjoyed to never play him again. Lost, I'm aready done with, but I'll go back for more once I have a few more achievements out of the way.
Lost: 7, Keeper: 1. I rest my case.
I put it because i did not research to actually say who is harder, so i didnt want to someone actually do the research and call me something like liar or idk.
Lost is strong, And usually finds 9 lives since he enters all curse rooms free and gets all devil deals that open free.
Both characters benefit from the new tarrot cloth item a lot.
I'd rather play Keeper over blue baby any day.
I never understood why blue baby gets so much hate: he is guaranteed to never lose devil/angel deals because he has NO red health to give. And it's not like finding soul/black hearts is hard. Yes, the poop is trash. But his stats are fine otherwise.
Keeper is just harder for me too. Lost's flight + devil deals + 9 lives/1 up/Guppy's Collar working so perfect for him just makes life seem much simpler, coupled with spectral tears to attack while hiding.
Keeper's biggest flaw is that he loses devil deals on one hit due to not being able to protect his health. If not for that and his slow speed he would be a much better character. He really feels like he needs something more. I do enjoy playing him once in a while, though. Especially if I get Tears up items. And he can easily milk any sacrifice room he sees (those this can be slow and tedious)
Also, in greed mode: the keeper is GOD! Literally next to invincible.
Start issac with guppy's paw instead of the D6, wham blue baby that gets 3 soul hearts to the hp up.
Besides if I never want to miss a devil deal, the superior lost.
I will admit that now though because of the changes in-game he doesn't feel quite as good as he once was. But still nowhere near god awful like some people say.
also it's incredible how good libra is as the keeper, you need stats afterwards but it's ♥♥♥♥♥♥♥ amazing when you finally have fire rate with the keeper.
Why do you think Keeper > Lost?
Um... Lost has the best odds for Devil Deals of anyone. All you have to do is survive. And Lost gets all Devil Deals free. All of them! Keeper can't take anything for 2 hearts without Judas' Tongue or he dies instantly and you need a health-up on that floor to even get a one heart deal. For Devil Deals, Keeper is literally the worst and Lost is the best by far.