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Boss armor renders any advantage you have so far null, such a dumb thing. It doesn't make the fights challenging, just tedious, he was so close to dying.
None can defeat the pretty fly.
try it
While brimstone is far superior, moms knife is pretty good in combination with anything that gives you a shield. It also synergizes well with the Ludovico Technique, items that give you poison tears and Tech X.
You could break a run with isaac, mama mega wil guarantee you're entrance to the void. All you'd need to bring along would be the poster. With enough damage it should be possible to one shot delirium.
If at any point before this you get hit and lose your mantle, exit the game, then continue. This will restart the fight but refresh your mantle. And can be done as many times as you want thus giving you infinite retries. :)