Can you miss achievements?

[RÆTIKON]

Went through the first playthrough just trying to get to the end and picking up any achievements I could along the way thinking I could go back and grab them later. But are some of them impossible to get after you get past a certain amount of the game?

[fertorma]

I don't think so

[Renegade Timelord]

It's been a while, but IIRC if you don't get #30 (the one that goes up the 'elevator' next to the central shaft) before you fight the eye monster, you can't go back and get it later. I believe I restarted the game at that point because I missed it the first time. I don't recall any others like that, but again, it's been a year or two for me.