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Huntress can spam her glaive once you get a couple rings with high crit. Slays everything hilariously fast.
Take Ceremonial Dagger, and glass artifact = ez 4-5 floors
8 stacks
thats best item strategy.
if you want play with command you need pick 5 hoofs minimal, and one infusion is good already, waste other green packs on icicles and will-o-wisps. all red items are good, thats why they are red, best orange item without any doubts is the clock.
4 heaven crackers + behemoth will help, lens makers glasses and wicked ring, infusion, missle launcher, 30 boxing gloves + 30 stun grenade is one of if not the best combo in the game, my play through is at 260 minutes and enemies physically cannot attack me. And just some various items like:
rusty jetpack, jetpack, rapid mitosis, goat hoof, red whip, time keepers secret, tesla, hopoo feather, barbed wire at 100 will insta kill bosses with 30,000 hp and i've killed colossuses with 500,000 hp pretty easily with it, guardians heart. And you're set for late late game.
Heart, Fungus and all healing items (1-2 for each) for defensive
Hoofs, Feathers, 1-2 Rusty Jetpacks for mobility
Syringe, Crowbar, Golden Gun, Glasses, Rocket for damage
For Miner 2 Alien Heads are absolutely necessary
Bandit and Han-D love the scepter
Crit Build + Ring for infinite skills
Clock and Shield are the only good oranges (except for rare cases) except for Miner who needs an Amethyst
Tesla, Ice Shards, Electricity Ring and Barbed Wire for overkill
Jetpack is absolute garbage since there are much better reds and vertical movement is covered with greens.