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Hardest: Necroa Virus
This.
My last post still holds; I don't even play Fungus or Parasite on scenarios any more. Not sure how the OP could say that Parasite was the easiest; maybe there's a strategy that I've missed completely there.
The two I have the hardest time with are necroa and fungus. The efficient use of spore bursts still confuzzles me to this day. Necroa was just hard to get out of the mindet of the rest of the game and use the plaugue as the set-up instead of then end game. I eventually got zombie attacks down pretty well though.
Hardest (so far) = Necroa. I'm almost convinced that you can't win with this thing without grinding for certain genes. They figure out how to cure it too fast, and the zombies are too inefficient to kill without piling up the DNA which you never have because, you know, gotta get dem hoards.
Fungus rides close second. The thing about that thing is that it's just a simple matter of spamming infectivity like it's the plague.
Edit: Not specific to Parasite; I'm seeing the same results with Prion, in both Global Warming and Ice Age scenarios.
Hardest: Shadow Plague/Simian Flu/Fungus
These 3 plagues I mentioned are a pain in the @$$! It takes Fungus a really long time to spread, Simian Flu can be tricky if you don't destroy the Research Labs and Shadow Plague is a mix of both... TRYING TO DESTROY TEMPLER BASES ALONG WITH RESEARCH LABS WHILE WAITING FOR THE PLAGUE TO SPREAD AT THE SAME TIME!!!!!!!!!!!!!!!!!!!!!!!!!