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Can you send me a link for a guide? I searched for one in Google for maybe an hour and couldn't find anything useful...
Started with transmission and the mutation upgrades. The deadly symptoms came just for free via natural mutation. Maybe just lucky.
Start in middle east/saudi arabia (the area that connects Africa and Asia), get Air, Water and Cold upgrades. Then pick up insect 1 (due to starting in hot country here) and bird 1 (bird is great for spreading). Pick up drug resistance 1 then get the other vectors.
Then simply wait a bit. Virus has a bonus to mutation and with all of the vectors you pick up, your mutation chance goes up. Once it has infected every country, get all of the virus mutation bonus upgrades. On max speed, you should get a mutation every other day.
Basically, I find the key thing for virus is to not buy any symptoms, except maybe the super deadly ones later on to speed up the death rate. You can up your mutation chance to crazy levels.
This is sufficient for Normal at least.
To be quite honest, this pattern works with everything I've tried so far. Use any and all gene upgrades you got. Especially Dwarism (sorry, uneducated so cannot spell. lol)