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AS SOON as Zcom appears send as much zombies as you can to that country so you can shut them down ASAP.
If you have infected atleast 60% of the world, and have already devolved 4 times, it's time to reveal yourself once the next mutation occurs. Start with the Insomnia symptom and work your way towards the zombies, but don't get the zombie symptom just yet. The insomnia tree slows research speed immensely. Milk DNA until the research bar reaches 50%. At this point you should have a good amount of DNA saved up. Get the zombie symptom and the million sized horde ability. Spread your zombies to any uninfected countries, and keep an eye out for Zcom. They normally start in Sweden, unless it's already been 50% infected. Once every country is infected, go down the symptom tree and then take a right. Then up and all the to the end of the big boned symptom. Your zombies are now extremely strong.
Once Zcom shows up, flood them with your newly upgraded zombies. Again, only the million horde ability will really do any damage. Keep upgrading your zombies, it doesn't really matter what you get at this point, just keep an eye on the symptoms that increase your severity by a lot. With Zcom gone, you should be able to wipe out the rest of humanity (unless all your zombies starved while you were focusing on the Zcom fort xD)
You only need to beat it on normal to unlock the next virus. If you meant unlocking traits, you can simply go back to any other virus on any difficulty and unlock all the traits that way. If you wanted to, you could do the bacteria scenario on casual several times and unlock most the traits.
Edit: As I finished typing, I just remembered that the Necroa virus has it's own traits. So yes, you do need to do the Necroa Virus multiple times. Sorry about that.
Genes:
Catalytic Switch
Darwinist
Aerocyte
Urbophile
Spliced Activation (optional)
Start in Saudi Arabia.
Buy these transmissions:
Zoonotic Shift
Rodent 1
Blood 1
Air 1
Segmented Genome
Wait until the cure progress is about 50%. If you're playing on Normal, your world should look something like this: http://steamcommunity.com/sharedfiles/filedetails/?id=259562502
Buy these symptoms (Note: Fever and Photophobia should have already mutated for free. If not, buy them first):
Delirium
Cytopathic Reanimation
Anaerobic Resuscitation
Enhanced Motor Control
Masticatory Tension
Anabolic Boost
Peptide Surge
Dermal Calcification
Buy these abilities:
Horde Instinct
Horde Mentality
Horde Vocalisation
Horde Pheremones
Start spreading to island countries that have no zombies and also send a horde from China to Russia and from Turkey (once it has at least 20 million zombies) to Central Europe. When Z-COM pops up, send a horde to that country from a country that has at least 20 million zombies. If Z-COM spreads to another country, sent a horde to that country from a country that has at least 20 million zombies. Start buying more combat symptoms to crush Z-COM:
Cranial Elephantitis
Bone Dysplasia
Enhanced Sensory Integration
Temporal Lobe Manipulation
Hyperosmia
Adrenal Surge
Lumbrical Hypertrophy
Acidic Reflux
Naja Mortis
Autothysis
As for more DNA, using the Catalytic Switch gene will allow you to continue gaining DNA throughout the rest of the game, even when there are only two countries left. This is because those two countries constantly send planes to eachother, initiating a blue bubble, which was previously useless unless you had Catalytic Switch. Each bubble is worth 1-4 DNA.
If you take a few transmissions that increase mutation chance, you'll mutate enough symptoms to cover the cost and you'll boost infectivity a little. For example, last game I played, I took Zoonotic Shift, Insect and Segmented (total cost: 33). I randomly mutated 5 symptoms before the cure hit 50%: Insomnia, Hyper Salivation, Fever, Photophobia and Coma (total cost: 34). A couple of symptoms also randomly mutated after I had zombies, so those three transmissions more than paid for themselves.
Use creationist, to prevent mutation, as it costs DNA points to devolve.
Start with Saudi Arabia, India, or China
Upgrade transmissions that DON'T increase mutation chance.
Prioritize cold resistance over heat resistance
Build points until a majority of the world (>70%) is infected
Go straight to zombies, get horde mentality and upgrades that increase combat effectiveness and horde population (DON'T do this if Italy, Greenland, or Iceland are not infected, as zcom forces in those areas are almost impossible to kill)
If zcom appears, attack them with your million-zombie army
Don't forget to move hordes to uninfected countries
Attack zcom countries until they die and about now, most countries will be 100% dead or infected
https://www.youtube.com/watch?v=P-IQ6beUDy4
This worked great, thank you so much!