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I have videos for every disease in the game (apart from Prion, which I forgot to upload before deleting the footage) on Mega Brutal if you're interested, where I explain why I do what I do.
It's great for generating the most DNA late game, but my favorite for most plague types is ATP Boost for a faster start.
Stealth is the worst way to go if you're trying to generate the most DNA because you will get no bonus DNA from severity. It's practically impossible to go stealth on Mega Brutal and win because you won't be able to afford lethal symptoms due to the massively increased costs from Genetic Drift. Genetic Drift causes DNA costs to increase as the percentage of world infected increases.
It's nothing compared to how much more you'd get if you started with a few symptoms.
Start out with some transmissions, then get Rash, Sweating, Skin Lesions, Cysts, Abscesses and Coughing.