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Edit oh its the other one.
Also the Segmented Genome is basically a mutation chance increase, but it attempts to do so as you infect people, instead of over time, so I'm possibly to assume that it is jsut more dramatic and often for mutations.
You can get it, but you don't have to in order to win :)
It is essentially a pre-cure thing. Mutations are tied in with new infections. If you evolve zombies before the cure is complete, you have chance to infect others (which will almost instantly instantly die from zombies/symptoms), thus you have a better chance of mutations. I don't think black/zombie symptoms have a set lower chance of mutating, it's just the way the game plays out.
I have never created zombies until the cure has been at a min of 70%. Zombies can't be cured so you should build your infected base up as high as possible before unleashing them.
Having said that, plenty of people have had success with concentrating only on a small area of large population (india and china basically), and then doing everything else with horde abilities. But I find that approach to be a bit hit-and-miss.
I tried several times, but there are several bases in the world, the cure is 100% by the time you are able to make your zombies. And you can not get the whole world before there are to many bases. And by the time your zombies are bit stronger, the bases are to strong and you have not enough zombies left to attack anything.