Cure Bio-Weapon with Vaccine

[T.K.]

Is there anyone with a Guide that actually works?

[S_Bahn_Berlin]

I don't know, but here is how I beat it:

Disclaimer: this requires a lot of luck, restarting and save/load.

It may not be entirely correct, as I only beat it once and stopped playing afterwards, and it was more than a week ago. Corrections are always welcome.

A few tips ahead:
* Play on Normal: the Achievement requires you to vaccinate against the Bioweapon at normal, despite not stating it anywhere.
* Always play on Speed 1 (the slowest), especially in the early game, because things can go rapidly wrong with the Bioweapon.
* Do not decrease the Infectivity too much, otherwise the disease will burn itself out and kill all its hosts before the vaccine is finished.
* Because of the former, Panic is a big issue. Use all possible tactics to slow down Authority loss. However, do not use Censorship and Fake News until the very end as a last resort, otherwise you lose 10+ Authority per day.
* I went with curing the disease when it's in Africa. South America may also work, but Africa has more countries, so you get more bubbles to pop and thus more Funds. Funds are a very limiting factor here. If it starts in Asia, Europe or North America, forget it.

Use the following advisors:
* Crisis Manager: You'll move your HQ a lot, and will always move it to the country where most people are panicking or dying. This will slow Authority loss.
* Surgeon General: Lowers Lethality a bit, and scales with the exponential scaling of the Bioweapon.
* Disaster Manager: Slow Authority loss from Deaths, because A LOT of people will die.
* Checkpoint Enforcer: Lifting quarantines is extremely dangerous in the early game, so disabling this is a good idea.
* Molecular Biologist: Speed up the initial research, because you want to unlock the vaccine development start, and Response options as fast as possible.

Edit: if you don't have unlocked all advisors, you can cheese through that process by curing Bacteria on Casual, saving your game right before the win and loading that save file up to 24 times.

1.) Start somewhere in southern Europe, e.g. Spain or Italy. Get "Investigate Outbreaks", "Government Partnerships" and "Deploy Field Operatives". As soon as you see the blue HQ icon pop up, pause the game and click on any country. This will make the Active Abilities pop up earlier.
2.) Fly around Africa: Libya, Algeria, West Africa, Central Africa, Angola. If it is not in these countries, start again. If you see a red plane or boat on the map, also start again.
3.) Immediately close Airports, Ports and Land Borders.
4.) Find the country of origin. The best are Botswana, Zimbabwe, Angola, Central Africa and Morocco, because they're far away from airports.
5.) Get "Furlough Schemes" and "Adapt Society". Move your HQ to whichever country is hit hardest. Also get "Targeted Economic Aid" to keep non-compliance in check.
6.) Put a full lockdown on Africa. Get "Mortgage and Rent Relief", "National Stimulus" and "Emergency Care".
7.) When the initial Research is done, immediately get Vaccine Research.
8.) Get "Targeted Quarantine", as well as "Declare Armageddon", "Expectation Management" and "Extreme Measures 1". The latter will make your operatives execute infected people, that will come in very soon.
9.) Always keep an eagle eye on South Africa, Egypt, Saudi Arabia, Iraq and Middle East. If they have more than 0 Infected, immediately use the targeted lockdown and set your HQ there to kill off infected. If the situation gets out of hand, which may happen by sheer random chance, start again. or load a previous save file.
10.) When your Funds allow it, get Field Research and Vaccine Manufacturing. From now on, you must balance your Funds between increasing Research speed and lowering Lethality. Start with Clinical Treatments and get the responses that also increase Vaccine research speed. If you have more funds available, also get traits to reduce Infectivity.
11.) Save your game. Get "Bypass Safety Measures". If the popup reads something like "xxx triggers early immune response", good. Your vaccine research will instantly increase by about 20%. Save again. If the other event pops up, your research is set back by 20% or to 0%. In this case, load your save file. Repeat until you get the positive outcome.
12.) Continue increasing Vaccine research speed, but get the traits that increase Manufacturing speed first.
13.) While decreasing Lethality as much as your funds allow it, let the disease burn through Africa. Don't decrease Infectivity too much or else the disease will not find hosts and eradicate itself before the vaccine is finished. You'd still win the game, but not get the achievement. .Do not let it escape past Iraq/Middle East/Turkey until your Vaccine research has reached around 90%. Keep these countries in targeted lockdowns if you can't execute the infected anymore. There may be a popup saying that anti-vaxxers destroyed a research facility. This will set research back by about 10%.
14.) When Vaccine Research reaches 100%, it enters the Manufacturing stage. Thanks to the speedup traits, it should already be at 90%. Now it's time to lift lockdowns and re-invest these points into reducing Infectivity and Lethality.
15.) Your Vaccine should be distributed within the next seconds and you'll win the game.

[Zwergboendal]

https://steamcommunity.com/sharedfiles/filedetails/?id=2403495183&searchtext=bio+weapon

Did it with that guide first try. (with some reload to get the correct spawn point - started in Angola for me)