Prion on Brutal

[Mr Krabs]

I’m sure there is a ACTUAL way to beat this stupid plague on this difficulty. Every strategy to have ever existed for this Difficulty on Prion never works. The Cure devolopes WAYYYYY too damn fast. I even tried to evolve Necrosis tree down when Greenland was half infected. The Cure always goes up extremely fast. It goes up to 50% in less than 3 minutes. It’s absolutely ridiculous. I’m starting to think this is actually impossible. I have very helpful Genes like Translecion+ and Darwinist.

[Spartan Delta 27]

I have completed Prion on Brutal.

The key is patience. Stay under the radar and constantly avoid developing any symptoms or animal transmissions. Air and Water work well without creating the additional possibility of mutations.

I will play through again on Brutal to see if there are some other tips I can throw your way

[Spartan Delta 27]

Alright, here we go.

Choose these starting Genes
Genetic Mimic (Just because)
Aquacyte (Just because)
Translesion (Devolving always gives points back instead of gradually starting to cost points)
Extremeophile (Just because)
Metabolic Hijack (No manually popping bubbles... Because it gets annoying when playing the long games)

Strategy
Start in India (Right below China)
Devolve all symptoms until you infect every single person. No taking chances, EVERY person.
Give your disease Air 1, Water 1, Drug Resistance 1 and Cold Resistance 1 + 2. Nothing else. Patience is key.

Now begins the waiting game. Wait until every single person is infected. Once they are, evolve the symptoms Insomnia, Paranoia, Coma, and Total Organ Failure. Also any I forgot to mention in that progression, plus all other super dangerous symptoms you want to evolve.

Then wait. If you want, improve cure resistance through the Abilities tree. You should win easily though.

[Mr Krabs]

What should I do about barely getting any points when I start killing?

[Spartan Delta 27]

Using my strategy, you save up tons of points. The key is to have a massive stockpile of points already in place and then evolve the symptoms you need to kill the population quickly when they are all infected.

If you do feel as though more points are required, you can let the game run by itself for awhile after you have infected everyone. Mutation risk should be extremely low and you will continue to get the stray point every once in awhile.

Basically the last leg of the strategy is to kill everyone faster than they can cure your disease. If you are worried it might not work, it might be useful to create a save at the point where everyone is infected.

[Mr Krabs]

Should these Strategies work on PC and Mobile versions?

[Spartan Delta 27]

Hmm... I only play on the PC version, where it works very well. As for mobile, I am unsure.

The underlying strategy is to not try infecting countries too fast. Minimize the number of points spent and avoid getting any symptoms until every person in the world is infected. It is basically just one big sneak attack, where you do not want them to know you are there until it is too late.

Keeping Severity down really low and avoiding lethality seems to work well at staying uncovered in Brutal difficulty and lower on PC. Megabrutal will always discover you at a point, which makes things really difficult.

[Olivier Batteux]

I have done tutorials on youtube a few weeks ago :

https://www.youtube.com/watch?v=dCcxWUPvfUY

https://www.youtube.com/watch?v=P5KPUT59fCQ

[Olivier Batteux]

And first, don't believe those who tell you to play with no symptoms at all, like only noobs do. It's what makes you miss DNA at the end.
When you "even tried to evolve Necrosis tree down when Greenland was half infected", you were extremely late to take necrosis "even" in this game.

You can't win challenging games if you don't play them. The game is to take calculated risks. I have done all the runs of my tutorial channel in 1 to 3 tries. It's not much, but it can't be 100% sure. The turorials promising a 100% in brutal lie.

[Mr Krabs]

So I shouldn’t go subtle? Even with the coughing symptom they’ll find me and start working on a cure in the blink of an eye.

[b34stm1lk]

Originally posted by Mr Eugene Krabs:

So I shouldn’t go subtle? Even with the coughing symptom they’ll find me and start working on a cure in the blink of an eye.

Yes

[Spartan Delta 27]

Originally posted by Olivier Batteux:

And first, don't believe those who tell you to play with no symptoms at all, like only noobs do. It's what makes you miss DNA at the end.
When you "even tried to evolve Necrosis tree down when Greenland was half infected", you were extremely late to take necrosis "even" in this game.

You can't win challenging games if you don't play them. The game is to take calculated risks. I have done all the runs of my tutorial channel in 1 to 3 tries. It's not much, but it can't be 100% sure. The turorials promising a 100% in brutal lie.

Hey! No need for bashing my play style.

I was just trying to help with completing the Prion on Brutal. The forum is open to anyone and I am glad that you decided to add in your opinion.

However, broadly accusing people of being "noobs" is unnecessary. I am just trying to help and that kind of language is what prevents people from giving input on subject matters which they might contribute something helpful towards.

I respect your experience on the game Olivier and appreciate your input. Derogatory language is unnecessary for conveying your knowledge.

[Sverd]

Originally posted by Spartan Delta 27:

Alright, here we go.

Choose these starting Genes
Genetic Mimic (Just because)
Aquacyte (Just because)
Translesion (Devolving always gives points back instead of gradually starting to cost points)
Extremeophile (Just because)
Metabolic Hijack (No manually popping bubbles... Because it gets annoying when playing the long games)

Strategy
Start in India (Right below China)
Devolve all symptoms until you infect every single person. No taking chances, EVERY person.
Give your disease Air 1, Water 1, Drug Resistance 1 and Cold Resistance 1 + 2. Nothing else. Patience is key.

Now begins the waiting game. Wait until every single person is infected. Once they are, evolve the symptoms Insomnia, Paranoia, Coma, and Total Organ Failure. Also any I forgot to mention in that progression, plus all other super dangerous symptoms you want to evolve.

Then wait. If you want, improve cure resistance through the Abilities tree. You should win easily though.

This no longer works. I used 150 ♥♥♥♥♥♥♥ points to develop every single massively lethal sympton in the game after infecting everyone on earth and they developed the cure before I had killed a billion people. The devs must have changed something dramatic because prion mega brutal is almost literally impossible to beat ATM.

[Spartan Delta 27]

Originally posted by Turnop:

This no longer works. I used 150 ♥♥♥♥♥♥♥ points to develop every single massively lethal sympton in the game after infecting everyone on earth and they developed the cure before I had killed a billion people. The devs must have changed something dramatic because prion mega brutal is almost literally impossible to beat ATM.

Unfortunately, my strategy does not work on Mega Brutal. I believe Mega Brutal allows your disease to be detected automatically once enough of the Starting Country population is infected. The method should work on Brutal, but not on Mega Brutal.

I apologize for not being more helpful in this regard, but I wish you good luck in your future attempts.

[Sverd]

Originally posted by Spartan Delta 27:

Originally posted by Turnop:

This no longer works. I used 150 ♥♥♥♥♥♥♥ points to develop every single massively lethal sympton in the game after infecting everyone on earth and they developed the cure before I had killed a billion people. The devs must have changed something dramatic because prion mega brutal is almost literally impossible to beat ATM.

Unfortunately, my strategy does not work on Mega Brutal. I believe Mega Brutal allows your disease to be detected automatically once enough of the Starting Country population is infected. The method should work on Brutal, but not on Mega Brutal.

I apologize for not being more helpful in this regard, but I wish you good luck in your future attempts.

It also no longer seems to work on brutal, just tried.

[Spartan Delta 27]

Originally posted by Turnop:

Originally posted by Spartan Delta 27:

Unfortunately, my strategy does not work on Mega Brutal. I believe Mega Brutal allows your disease to be detected automatically once enough of the Starting Country population is infected. The method should work on Brutal, but not on Mega Brutal.

I apologize for not being more helpful in this regard, but I wish you good luck in your future attempts.

It also no longer seems to work on brutal, just tried.

Odd. I will give it a quick go and see what happens