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Besides your melee, use weapons with high damage per hit for the enemies later in the loop. Think crossbows, sluggers, etc. Simpler is easier to use and probably better for you (don't be afraid to experiment). Thier faster varients are even better. Explosives can be great but risky.
For mutations, get at least one that let you get health more easily (Bloodlust, Rabbit Paw, Second Stomach). Rhino Skin and Strong Spirit are pretty important when you have so little durability. Boiling Veins and Gamma Guts can save you from explosive and contact damage enemies, respectively. Plutonium Hunger lets you get pickups faster and more safely and easily. Stress lets you survive stressful situations more easily. Long arms is amazing once you realize the potential of melee. Trigger Fingers and Impact Wrists are great for crowd control, the former more so. Euphoria is nice but low priority. Scarier Face is great for obvious reasons. Every toher perk is meh, except for Laser Brain if energy weapons are your thing.
That's the most help I can give without knowing exactly what you're having trouble with.