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Plenty of guides on her
once you start to unlock the full potential, it will all work out
'hard mode'/'new game plus'. It's unlocked once you complete the star map. It adds about 100 levels to every node as well as increased resistances. In exchange, you can be awarded special resources for powerful arcanes, as well as increased resource drops.
Mesa can work there but you need ways to heal yourself when situation demands it.
Equilibrium (Warframe)
Blood For Life (Warframe's Parazon)
Dreamer's Bond (Warframe Aura)
Medi-Ray (Robotic companions)
Sacrifice (Sentinel Companions)
Transfusion (Vasca Kavat companion)
Healing Return (Melee)
Life Strike (Melee)
Give Mesa more range so that her Shooting Gallery (2) can jam enemy weapons. Her Shattered Shield (3) gives 95% damage reduction with +30% Strength or 80% without any Strength mods. She really shines with Peacemakers because she gains more attack speed as long as you hold shooting button down and she doesn't care where the enemy is as long as they are visible on your screen.