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Opticor or Lanka does well, but things like a Supra with punch through and high status can rot them down.
Nidus has 2 things he doesn't deal with well:
1: AoE.
2: High armor.
For the AoE you want weapons like the Lenz, Zarr, Arca Plasmor, Amprex, Pox, Staticor, Atomos, or Zenistar. These all can deal with large groups really really well.
For high armor you want a weapon that either doesn't about armor or can strip massive amounts of armor. Tigris Prime or Kohm (with a riven that lets it gain 100% status chance before multishot) are generally best for the former, while Mara Detron or Pox with a Corrosive/Blast 100% status chance build are best for the latter.
Zarr
Acceltra
Ignis wraith
Fulmin
Catchmoon
Any melee
GG
I have some different builds but these are the ones I like the most:
- Equipping Teeming Virulence augments for tons of crit and the LENZ, have in mind you'll have to mod the frame with decent range (I go with 240 range).
- Again Teeming Virulence and ARCA PLASMOR, I go with medium range
and focus on strength (more than 200)
- Teeming Virulence, medium-range, medium strength, lots of survival and the ASTILLA
All the weapons that I enjoyed playing with Nidus:
- Arca plasmor
- Astilla
- Hek
- Ignis wraith
- Lenz
- Zarr
You also want something to deal with null bubbles and arbitration drones, like a rapid fire and a high single target damage crit gun, unless you are among these 95% of the player base who can't aim to save their lives, then you want to use some crutchmoon or something and maybe not use frames that require some effort to use effectively, like nidus, in the first place lmao.