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So thats something you need to choose between.
http://steamcommunity.com/sharedfiles/filedetails/?id=887768404
With that, his 1 travels an extremely long distance, his 2 lasts for a decent amount of time and grabs things from quite far away, his 3 lasts foreeeeever and 4 can rock out for about 2 straight minutes, giving you plenty of time to generate a heck of a lot of mutation stacks. At 100 stacks (max) he normally hits for around 250k per enemy on a 1.
Nidus is all about building those stacks up, so the longer your 4 lasts and the further your 1 goes, the quicker you build stacks, so the crazier your damage output becomes and the harder you are to kill.
High Strength
Moderate Duration
Moderate Range
Low Efficiency (Rage and 1st ability gives back more energy - just use Primed/Flow for a higher pool if you want)
Nidus isn't really that kind of frame. The build I linked should easily allow you to outrange Frost with your 1 vs. his 3 or 4, but against a frame like Ember or Equinox who have mobile AoE Nidus will always fall short. He's very much a static situation frame, where he does his best work in a defensive position, moving around puts him at a disadvantage because of the slow animation lock of his 1, and the inability to use 4 to any beneficial effect.
but personaly i like pure strengh nidus.
ends up with something like 280% strengh or something like that with all the strengh mods other then the drift one (i could use it if i was not using a bullet jump mod, but that moblity though)
the cost for using skill 1 or 2 is high, but the build is made for high level with lots of mobs.
with skill 3 i get a 70% increase in power with me and who i connect with, getting me to about 350% power. mind you this is at like 0 stacks.
the energy return on his first skill, is that if you are hitting 4+ mobs then you will not run out of energy. this along with Rage mod lets me run with -55% effeicncy without problems
4th skill cast while 3rd skill is active gives you about 97Hp regen/second.
at base values and low stacks nidus is strong. in thoes endurance missions getting to 100 stacks makes nidus able to take on mobs way past level 100.
Strengh is important because it is the base value on which your stacks scale, at base power you can concider that Stacks are = to the level of mobs you are faceing, IE. level 50 mobs, will be killed by 50 stacks farily easily, and so on.
with a pure strengh build you are way beyond this limit and are much more lethal at lower stack values.
Duration is important for presveration of stacks. the less you have to use 3rd and 4th skill the more stacks you are able to hold.
range has function but imo is the least important of the skills. range can be very useful but with the base values of range, nidus is already able to CC at a decent distance with his 2nd skill and 1st skill travels a more then decent distance.
Really nidus can be built many ways and all be lots of fun. i just like being super sayan at 0 stacks and like super sayan 4 at like 100 stacks.
pure strengh build really supports other playes as 70% increase in strengh is insane to be given to another player for ~ 60 seconds.
tl;dr
Strengh build = feel OP all the time
range build = master of CC/ clumping mobs together
Duration build = get longer use out of 3rd skill and 4th skill
^ what you want is how you want to play nidus