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The signature skill trees also unlock a unique version of one of the skills & gives you maxed mods for that skill, and some signature weapons also gives you a unique/stronger weapon attachment!
But most of them are really good and has nice dps, especially the flamethrower if you run a burn/status build imo.
A random video that shows you some of the passive skills in the different signature weapons:
https://youtu.be/B7zF9hKmvdo?t=58
EDIT: enemies that you kill can & will drop special ammo for signature weapons.
There is a green gear set that drops bleed ammo for you > which the survivalist signature weapon benefits from "if I remember it correctly"?
Will say that the Minigun syncs well with the Striker and Negotiator's Dilemma sets!
When you've played for a while and teamed up to do heroic and legendary content, you'll notice that very few people actually use their signature weapons.
As the others have mentioned, it's the buffs you get from the specializations that matters. The weapon itself, not so much.