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SMGs and rifles fair particularly well against them due to their faster fire rate, which makes it easier to prefire their weak spots before they even show up. You can also use weapons with Piercing that will completely remove the need for them to expose their chest's weak spot - just keep shooting at the chest where the orange blob usually appears, and they should die quickly.
Alternatively, wait for them to expose the blobs on their shoulders, and use a Magnum to take them and their chest blob out in 2-4 shots depending on the Magnum you're using and the difficulty you're playing on.
If you're playing with infinite ammo however, the Rocket Launcher is a 1-hit kill against them as long as the rocket is shot and lands right at them.
https://residentevil.fandom.com/wiki/Reaper
I guess you didn't pay attention to what I said in regards to the Grenade Launcher - why use 2 Flash Rounds (if they even work / have an effect on the Reaper) when you can use a single Electric round that's a guaranteed stun for him ?