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1. Use your eyes before your fingers, with regard to the QTEs. You have time to make the input. This is the only area where another player would be stronger, because if one person gets the QTE right it saves both of you.
2. When he is about to stomp or fist-slam the Jeep, don't stop shooting at him. Stop shooting as soon as his attack is snubbed so your gun will cool down.
3. Shoot the guys who spawn on the left and right only when he is pushed back.
If you still really need help I'll do it nbd.
I finished a playthrough on professional and the Ndesu boss fight remains perhaps the most dreaded one on that highest difficulty (the second being the Wesker/Jill scene which can be trial-and-error).
What worked for me like a charm ON THE PC version:
Use keyboard and mouse for this fight. Rebind several of your controls -- it's not complicated, and easy to change back. Go ahead. Do it. You know you want to.
I'm assuming directional controls that are either numerical keypad or WASD.
Set "context action" to left mouse button. Set "partner command" to right mouse button. Reassign "fire" to a proximal key such as keypad 9 or the letter E, depending on your directional control (numpad or WASD). so you can simply press with your left index finger to fire.
What throws some people is that the game switches up the prompts so you either have to hit left-right together, or else hit context-action and partner-command together.
With this streamlined key binding scheme, when you see a prompt, you don't have to interpret it. Simply reflexively mash both mouse buttons and both left-right buttons at the same. You cover both possible combinations, and the game registers it every time. You've got both hands pressing a left-right combo and it's extremely intuitive and works like a charm. Then you can simply go back to pressing the nearby numpad 9 (or E) to continue firing.
This frees up A LOT of gray matter so you can now focus on the fight itself.
Secondly, turn off the volume on your speakers or take off your headphones. It helps keep your anxiety down, and this fight is all about visual cues.
Now that the QTE's and the racket are basically not sticking in your craw, the fight becomes a matter of weapon heat-management and prioritizing fire.
Most of the rest of these hints are already posted elsewhere on the internet:
-- manage weapon heat; make sure you reserve enough firing allowance to stop Ndesu's charges. Hit him in the face or, some people think shooting the foot to stop his stomps. I merely concentrate on the face at all times.
-- there's a possibility that he will do a particularly nasty rhinoceros-like charge from a distance. You must focus on his face to stop this, because it will reduce your health by a huge amount.
-- You can stop boulder throws by shooting the boulder as soon as you are able.
-- You can stop telephone pole attacks by hitting the barrels right away (in pro the one on the left is nearly hidden and needs to be fired on immediately or else Ndesu will advance beyond its explosion). If you miss the barrels, there's usually two QTE's to duck, and one direct attack that can be halted by the face-shooting routine.
-- there's a chance -- not always -- that he will cause a particularly nasty QTE prompting you to "grab on." When he sort of starts flailing around upright from a distance, without any cut-scene, get ready. It's a very small window on that particular prompt, and it's easy to miss his visual cues.
-- keep an eye on the Majini that appears to the left on the balcony. He is also a high priority. Shoot him the second you get a chance, as long as you're not stopping Ndesu's direct assaults. Shooting the smaller Plaga-thingies is secondary to this Majini.
-- the two guys on the right are low priority, you can take them out as you are able.
-- when the stalk-like thing pops out of Ndesu's head, I found aiming high on that entity, near the top, seems to be most effective.
That's all I've got.
I will also post here my advice from the other thread, to make everything "be-in-one-place". hope it will help some random players
---
1) reduce your graphics to minimum and set fps cap to 30. that battle (especially destroying of boulder) is fps-dependent, and if your current fps is low, you will never destroy the boulder and the firerate of guns would be lower
2) assign your a/d and f/v buttons (of whatever your qte buttons are) on the same button, like s. whenever qte happens, just smash s and you will be good (yes it works on pro mode)
3) whenever parasite appears shoot at its white round thing, that is actual weak spot (deals x1,1 more damage). overly parasite has 11,000 HP with precise shooting you can deal about 6,000 damage in a round, but it \is very unlikely due to recoil and wasting few frames on aiming. so you need three rounds to kill it on pro (on other modes you can kill him in two rounds)
4) mind the Molotov guy on the left, he deals a lot damage. don't mind the guys on the right, they are annoying but not the top priority. they all have a 1 HP, so a single bullet will instantly kill any of them three
5) play as Chris, put Sheba-bot on the Gatling gun. the AI is way better in handling Gatling gun than a human (and never overheat)
6) barrels do deal extra damage to small parasites, but boss must be very close to it; mostly it is better use them to cancel his boulder or poll attacks
7) whenever he is away from you, shoot those small parasites that are most far from his head, because when he comes closer to attack you and you will concentrate the firerate on his head you will eventually hit small parasites closer to his head
8) shoot his head to cancel all his attacks (some guides says shoot at neck or foot, but don't mind those - always shoot at the head)
9) as far as I concerned, you and your partner/AI should deal a certain damage to his head to cancel his attacks (say you 500 HP and bot 500 HP). if you shot his head hard, but boss still attacked you - it means your partner didn't hit the needed pool to cancel an attack, blame him
now for my tips and tricks.
1. bind an unused key to A D E F and V. that will help you with all QTEs.
2. if you're not a pro gamer just ignore the pole barrels as you can just QTE his swings and shoot his head to cancel his smash.
3. when he charges from a distance don't do what everyone says (shooting head), instead shot his shoulder which will make you shoot his head when he does charge.
After dying an infinite amount of times (the giant would kill me with 3 hits) it was so ridiculously easy to deal with after changing the keys, and to deal with the rock he throws at you, Idk why exactly, but it helped me a lot to zoom out all the way to shoot the rock, and it never hit me, the only hits I received were from the regular enemies around the arena.