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In conjunction with boarding you don't use it while your crew is over there. You fire it, then invade the ship which now has crew so badly wounded that even engi have the numerical advantage in a fight.
You can also use it to speed up the O2 strategy you mentioned. Having 60 less health means they have much less time to repair it before they suffocate.
To be perfectly blunt, you don't.
It's a piece of ♥♥♥♥.
Sell it off and buy something that actually damages enemy ships.
I'm a bit of a pyro. And fire beams are vastly more efficient ways of turning an enemy ship into a s'mores factory. Unlike the anti-bio beam, fires spread. There is nothing more catastrophic to an enemy than a ship where every room is a blazing inferno.
I love fire. Fire. Fire. Fire.
ETA: I should point out the fire beam is only slightly better than the anti-bio beam as a weapon. I just like fire. It's objectively a pretty terrible weapon, though, against most ships. It is reasonably good against large ships where fire spreads, and especially the flagship. I just really love seeing every square of a ship burning.
http://steamcommunity.com/sharedfiles/filedetails/?id=339311148
Or, even only one can have this result:
http://steamcommunity.com/sharedfiles/filedetails/?id=332569531
The problem is this is a rarity. You have to hit crew repeatedly to kill them with this wretched thing. If the enemy has a medbay, it is utterly useless. Plus, crew start moving around even while the beam is cutting through them, so unless you have one of those ships with straight passages, they're moving out of its way.
This is just an objectively awful weapon.
ETA: I must compliment you though for an elegant use of breach weapons. I also note you are apparently a fan of murdering the entire crew on phase one. I do that too.
That's a very good point for making this crappy weapon semi-effective. However, I have only ever pulled this off accidentally.
In fact, I have yet to get the anti-bio beam achievement.
once your bomb hits the shield generator, set your beam to hit both the guy in the shield room, and along the path of as many crewmembers incoming to that room as you can.
depending on your timing, and the enemy ship layout, you can have almost all the crew dead in one shot.
the bio beam isnt too bad, but i do prefer weapons that can actually do damage. augmenting the bio beam with an ion weapon just makes fighting the boss that much more difficult.
Easiest done against an early game mantis ship. No medbay, and the helm, shields and... weapons, is it? Are all in a line in the left wing. Two shots and they're gone.