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the reason is that both sign and alchemy have their utility further down the tree, so you need a lot of points for any good benefit, while sword utility is more consistent throughout it.
for the alchemy tree you should consider the following: you want impregnation - the skill that improves mutagens - and the mutagen skills i.e. the few last ones. whis is a very bad combination with sign heavy build that requires you to max out skills before going down the tree and picking up the mutagen skills.
iorveth path was more fun for me, it's also better for experienced players because of the xp distribution in chapter 2.
going sowrd+alchemy is a pure sword focus build that increases damage to ludicrous amounts (yes this can kill humanoids while they block your attacks with one hit). tbh due to it's nature I'd only recommend it for an insane run, because everything else would be overkill (those upgraded mutages are always active btw even when you have out of character battles like in the ghost battle).
if you wanna do a very spell focused build, I'd recommend you pick up the bare necessary sword utility (dodge, what else), focus on your signs and maybe go into alchemy in the end, probably only going for the impregnation talent to give yourself the endgame edge.
your skill distribution may be very loose when it comes to almost any build, I think the sword/alchemy route is the only one that uses every point effectively (to do more damage) and thus very strict in what you take and what not. apart from that one all (not pure alchemy) builds are almost on the same level of strength,utility and viability, so just test things out if you like.
Are the dodge upgrades worth it? I never picked any up until right neat the end on my sword build when I went with one. While I thought the first upgrade might be useful, I preferred to not put myself too far away so that as they swung and missed I could do a power blow to the back, which the upgrade would position me too far away to do, Certainly didn't seem essential.
so no, the second one is not needed. mind that you want to keep your distance with a sign heavy build, so it actually makes alot more sense if you bombard the enemies from far away^^