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more objectively destroy debris within radius feels the best for me, as those chances to get pick up are less likely to be missed
If you are struggling for the boss the extra 3 health+ black hole after beating one is nice, you will appreciate them if you lose tons of health on them
hope it helps, I havent tried every upgrade yet so it is just personal experience.
Salt the Wound > Battery Lick is also pretty good.
Later on, things like Reroll are helpful, too.
Hunting Season will make bosses a lot more manageable too.
Rainbowsplosions is also a great one because it helps clearing out hordes.
Another two good ones are Marathon and Exponential Expedition. The first will increase your movement speed temporarily on kills, and the second is a GUARANTEED movespeed increase depending on Mortality. It really makes the difference in running circles around bosses or spending all of your black holes to try and survive.
Shocking Results + Connect Call = free levels = more survivability (the "everything dies faster" type)
Unsure of how worth Expert (+5%xp) and Blood Soaked Sword is. I grab expert because 5% feels like it'll have impact. Blood Soaked Sword is like High Roller, only considered if you can guarantee 3+ flawless kills. Especially after lowest difficulty, I don't think they're worth.
Salt The Wound feels obligatory, haven't figured out what 1% effect chance I like.
Drill can be really nice, but I've shifted to a more RNG-dependent build, so I don't have tons of rerolls to mess around with like before.
Nitrous +1 damage has a lot of impact on certain weapons but generally you can't go wrong with taking it. (Same skill tree investment lets you acquire Hunting Season which is also top tier)
Hunting Season -20% Boss HP speaks for itself
Confidence - 15% movement speed for not getting hit is really nice, and the skills before it that it stacks with make you quite fast compared to normal which does a lot for certain scenarios. (I personally spec into Marathon>Gaiden/Expenonential Expedition/Confidence)
Space Lightning - Kickstart your run with a free level! Get rewarded after every boss. Feels good and is good!
Connect Call The quality of life and consistency you get from receiving all EXP from any given level is not replaceable.
If you want to spec into survival I'd recommend:
Meal To Go>Void Scream>Battery Saver>Chrome Plating>I Must Scream.
Statues/Drills can be great, that's up to you!
These are what I'd call the truly good skills. Re-rolls can let you cheese into the same OP build every run if you really want to for a flawless run or whatever. But that's no fun is it?
I run 1% crit but it's not actually a major impact, it's just fun to crit. 1/100 hits doing 3x the damage is practically nothing in the grand scheme of things if you do the math, so just wanted to point that out.
I'd recommend skipping bans and rerolls unless you are achievement hunting.
You can usually get a good build out of getting a mob weapon and a boss weapon, then continuing to choose weapons and upgrades based on what +stat effects benefit them the most.
Have yo-yo & flamethrower early on? battery + injection --> shuriken, bouncy balls
Have turret & headphones? digiwatch + battery --> core, missiles, core
etc...
It's frustrating when you know exactly how to move to dodge a pattern only to get hit by it because you are not faster enough to execute the movements.
I would also put Collect Call in the Absolute Must Have category. A free magnet before every boss is a no brainer, you can very well end up missing out on experience without it. Space Lightning you could probably live without but anything that gives you more upgrades is worth it in my book, and it's on the way to Collect Call so you might as well take it.
Expert's +5% XP increase doesn't sound like much but it makes a noticeable difference in the time that it takes to level up.
Meal To Go and Spaghettification gives you guaranteed health and bomb pickups in a game that can be very stingy with them at times and at one skill point each they're shockingly cheap. Kind of a no brainer, although if you're planning for a no damage run or think you're good enough to get by without them you can save the points for something else.
Salt The Wound is free extra damage if you use anything with elemental effects, which I often do. The +1% elemental effect skills sound absolutely pitiful and not worth it but if you have weapons that hit things very very fast like Eye2 you'll actually trigger these effects more often than you think. Actually quite helpful with Worm and Biker as they'll be stopped and slowed by Shock and Freeze pretty often, and all four elemental effects are also free damage as well.
Statues and Drills add a little spice into your runs. Drills can actually be helpful if you don't have enough slots for something like cooldown speed or weapon size but have enough stats in something else to temporarily sacrifice for them. You can also just get straight upgrades that give you more max health and bombs with no downsides.
Lastly, Skips and Rerolls drastically reduce the effects of RNG. Going all in on them will let you bend the RNG over your knee and spank it until it cries for mercy.