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easiest way to fight bosses I found was just full auto shotgun burst on them a few times and they just die
and tunnel rat does make them even more amazing
Helps that shotgun ammo is the second most common lootable ammo type and nearly every faction has shotguns with ammo you can keep looting. Even the alternative shotgun ammo types aren't particularly rare to loot.
By comparison, other BS stuff like abusing the wheel of pain isn't as reliable simply by virtue of having less reliable ammunition and no way to further boost it using class skills.
Once you get into the midgame and no longer have to worry about weapon durability and ammo as much as you do in the early game, viable weaponry options open up. Shotguns are great for clearing out rooms of trash mobs, but have a bit of difficulty with the chonkier Quasimorphs. A Volcano energy weapon can unmake most Quasimorphs in a single burst even on higher Quasimorphosis levels, whereas an automatic shotgun will require three or more. Assault rifles become a middle-ground between the two, since they deal with inaccuracy via volume of fire with per-shot damage that outclasses shotguns.
I usually run a build with a shotgun in primary and an energy weapon in secondary. Use the shotgun to clear rooms of trash/Human enemies, then switch to to the energy weapon when dealing with Quasimorphs.
If you want to try something else, you can take the character who boosts pistol accuracy, make them a Spaceborne Ghosts class, and give them two pistols that use different ammo types. You can effectively sprint in every fight and still hit with almost 100% accuracy.
Unfortunately, you can still miss with them or not kill in one turn and die in one hit because the game's balanced is super scuffed like that. I basically always run tunnel rats and I can go through 10 missions in a row, do one Tezctclan mission, either miss or low roll someone using a cold gun and that's it I am ♥♥♥♥♥♥ in one turn.
Theoretically that can happen with buzzsaw cutter as well but humans tend to die more consistently than these hell clowns.