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You can't randomly catch it out of nowhere, as mentioned above. The Dragon Plague can only be caught from dragons, then can spread from an infected pawn via hiring through the rift. Pay attention and you should have no problems with it killing your town npcs or infecting your pawns.
Just talk to your Main Pawn before resting in your House / Inn.
Eyes will glow every 4 seconds, it's super noticeable.
Can I instantly test brand new pawns?
Wandering pawns also have it.
https://www.polygon.com/dragons-dogma-2-guide/24114907/dragonsplague-symptoms-cure-signs-eternal-wakestone
However, it doesn’t tell me if I can be ever 100% sure if all my new pawns are 100% healthy.
Though, this plague annoys me and I didn't wanted to deal with it on my NG+ so I installed a mod that disables it completely because I wanted to focus on exploring and completition.
If are willing to use mods, there is a mod that displays the lvl of contamination of your pawns (1-10, at lvl7 they infect others) without disabling it.
So your pawn can get the dragonplague from a seamingly normal pawn you recruited in the rift.
The red eyes is the last step before they trigger the dragon's plague if you rest in an Inn.
You don't trigger the dragon's plague if you rest in an inn if they don't have the red eyes.
For example, my first encounter with the dragon's plague in my game was when i recruited an infected pawn in the rift. Got the message (tutorial) right when i recruited him.
I then check he was perfectly normal, no red eyes etc.. and same for the other pawn.
Ended up in the Brine just in case anyway.