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You can use everything you want for S+ runs. Just for the handcannon .. there is the bonus weapon limitation.
To get handcannon you must complete professional difficulity without using bonus weapon (primal knife chicago typewriter etc...) but you can play at your one pace there is no save or time limits. And you can use accesories (like cat ears) which will make it very easy.
I really suggest you to separate theese two goals. Or it will be very frustrating.