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The bugs (Novistadors) were experiments by a Saddler scientist, an in game file said this.
Saddler and Krauser kidnapped Ashley because:
1) He wanted to dominate the world, Ashley being the presidents daughter sends a message. She would be returned home infected and spread it since she had a dominant strain.
2) Krauser hates the U.S Government because of Operation Javier in which they screwed him and his team over (said in files and dialogue.) They left them for dead.
3) Krauser helped kidnap Ashley as revenge on the U.S gov as speculated by Leon.
4) Saddler is a cult leader obsessed with a religion his family headed for generations, Los Illuminados, the plaga is central to it and his means of controlling people.
5) Saddler hired Luis at one point who once worked for Umbrella.
6) Ada is working for Wesker (also formerly Umbrella.)
You weren't paying attention, clearly.
They want to infect her with Las Plagas so that they can send her back to the United States under Saddler's control. Once she's back, he plans to have her infect the president with Las Plagas so that he can control the entire country and eventually infect the entire world.
This is possible with the Dominant Plaga which everybody and their brother is after.
I'm pretty sure some notes in the original and probably in the remake go over the plans why they did this.
Sadler is the guy every RE game has, where he discovers the power of this specific semi-immortal parasite creature and is the one to utilize it for his ultimate evil goal.
All of the gaps in information are usually handled in notebooks or journals or on the backs of photographs. So the info is there, usually. But you gotta find it and piece it together yourself. Or wait for a DLC. But they usually don't do much story DLC for the remakes.
Yeah I just rewatched that cutscene. Ramon Salazar says "With that girl as the very source, your United States, and then the entire world shall overflow with his grace. For that is the iron will of my master, the most holy Lord Saddler!"
And that's all. One entire sentence explaining why they kidnapped Ashley. Really not much of an explanation.
Umbrella is clearly involved somehow considering the photo you find of the "European Umbrella Lab" showing an entire crew of Umbrella people in what appears to be Luis's lab. Seems to be trying to say that the entire island facility was at one point an Umbrella facility.
I think this proves my point that the story is pretty vague considering people have conflicting explanations just in this thread alone.
The only "tie" is that supposedly Luis got inspiration from Las Plagas to help create the NE-α Parasite, Aka Nemesis.