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"Saddler's research team began experimenting on these organisms,[7] and created a large number of Plaga eggs for the purpose of spreading out to the entire region and, eventually, the world.[5] From this research, Salazar was granted one of several genetically modified dominant species Plagas, which would grant him full control over his body as well as the ability to control rank-and-file hosts. Salazar formed a large armed force of Cultists, and used two Verdugo bioweapons as his personal bodyguards. It became Salazar's duty to protect the Queen Plaga, a large creature which asexually reproduced new Plagas constantly."
https://residentevil.fandom.com/wiki/Ram%C3%B3n_Salazar