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I'm at the cabin fight and i'm around the 1h 30m mark and i'm not sure if I should go back to earlier chapters to tighten up my playtime.
So basically, go as quick as you can, try not to save much and if you die restart from a clean load instead of clicking continue.
Most importantly if you haven't tried it use the Bolt-Action Rifle (commonly called BAR on here) WITHOUT a scope. It is much easier to handle at mid/close range this way. It can also trivialize encounters. For example if you upgrade it in a Pro S+ run with enough upgrades (not just dmg btw) it can beat the first El Gigante before the boss ever takes a single step. This requires enough dmg, naturally, but also enough ammo capacity and fast enough reload rate (reload makes a huge difference on weapons like this that reload one bullet at a time if not upgraded). Cabin? You can kill 2-4 enemies at a window or the stairs in a single bullet or obliterate the bull special enemy when it spawns for an easy cabin siege. Double Garrador fight? A single heavy grenade followed by 1 BAR (upgraded dmg and exclusive) round to the back plaga will kill them (aka 2 bullets, per per Garrador, and a single heavy grenade hitting and stunning both) for a easy win seconds after the boss fight starts. Etc.
Riot Gun, the shotgun, isn't just about doing good dmg. It is great for cutting time waasted on combat and avoiding having to actually kill targets. Simply get decent ammo capacity on it and you can run through rooms like the water room just shotgunning anything that gets near. The goal is to knock it away/down and run past IF it gets near you, otherwise obviously you are running past. You can kill stuff and still S+ but doing this makes some sections much easier than actually killing dozens of enemies and soaking up bullets, healing resources, etc.
Pistol? No. Toss it. Get the TMP (since LE 5 is so late in the game you can swap when you get it if you want, weapons sell for almost all the money they had spent on them) and use it as a pistol replacement. As long as you get used to not spamming too many bullets, aiming properly, and using it at proper ranges with the stock it can headshot as well as a pistol and be far more ammo efficient but stuns better and does more DPS. The core gain here is the ammo efficiency though as you pick up 30 bullets or craft 30 (+15 with bonus for 45) which maths out to making pistols look like trash. Aside from some preset static ammo placed around the game's world your enemies will drop ammo based on what you are holding so rather than dropping pistol ammo they would drop SMG, rifle, shotgun ammo if those are the three weapons you hold. If you feel confident though it is totally viable to just go shotgun + rifle only though.
Flashbangs are great for running through areas as are grenades. I recommend hording them and not using except when actually needed. I recommend gunpowder case. Further, I recommend NOT crafting stuff and stockpiling gunpowder/resources (except when you need space) so that you preferably get most of your ammo via direct drops on ground (mobs/boxes/barrels) as you get low. If you keep crafting then it spoils the RNG making ptas drop more than ammo that you want wasting gunpowders indirectly plus meaning you wont have the gunpowder for clutch ammo situations or better yet clutch grenade/flashbang situations.
Ashley Knight armor is nice to have but really not necessary. Mostly it just makes the knight armor section a breeze as you cannot die with it.
Skip exploring extra stuff you don't need because, again, resource drops are based on what you have and what you need so grabbing extra is only padding you slightly if already well of meanwhile if you need resources the game will favor dropping them anyways so no need to go overly out of your way.
Fish from the fountain and lake are great free chunks of health you can horde that take hardly any time to gather at the expense of inventory space.
Gold egg trick for Salazar Ramon.
Magnum sucks. Buy rockets instead. Preferably at least 1 rocket for Vergudo (he must be frozen for it to kill him, so first time he comes out freeze and rocket him skipping that entire section's combat) and 1 for Saddler. If you can spare the money then buy one for Krauser's 3rd form, too.
If you want when you do Pro you can also get the Chicago Sweeper with its infinite ammo and really trivialize the run.
There are some tricks to save time such as the scope skip bypassing first Garrador and related segment and the crane section and related segment (otherwise grenades on the wall will break it asap instead of using crane ball). Throwing grenades for the red guys who chant can trivialize their sections like if thrown as you run across the bridge and timed right you will prevent the bridge from dropping skipping that mini section or for doing high dmg to the one with the bug room. Then snipe it or run up and shotgun it real fast. There is a mine trick with the bolt gun (if dmg and other stats are upgraded high enough) that will instantly kill the chainsaw sisters and mendez then you can sell the bolt gun after for almost all your money back just make sure to have enough resources to craft the mines/bolts in advance.
Cutscenes don't count against timer but you can skip them if you want. However, do NOT load your game from during a run or death screen as this adds time to your timer. Exit to main menu to perform ANY LOAD game action.
From there it's just a matter of grabbing certain treatures and individual strategies for forced fights.
Alot of those door skips seemed to have been patched out. It doesn't specify which ones but I just tried the Garrador skip and I couldn't get it to work.
https://mp1st.com/title-updates-and-patches/re4-update-1-005-howls-out-for-april-23
https://www.speedrun.com/re4r?h=NMG-PC-Professional&x=02qw4x72-rn1jrq1n.1w4vyovq-38dm71z8.1py39o81
https://www.bilibili.com/video/BV1Wa4y1K7bR/