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Its a viable handgun.
Unfortunately, while its dmg barely beats Blacktail it loses a ton of reliability / mobility with its poor fire rate handling multiple enemies, staggering for melee or simply to prevent them from attacking you, for countering weapons and follow up hits, for DPS purposes it loses quite hard (it might have high dmg per shot but extremely poor DPS due to awful fire rate and precision), lacks laser sight (both do but its reticle makes it even worse than usual), and it doesn't handle turning or running around well.
Overall, the Red 9 is viable to beat the game with certainly but its quite bizarre why the gun hasn't been buffed yet as its clearly so much worse than the other pistols. I wouldn't say its as bad as the Skullshaker, which aside from an extreme niche is genuinely dumpster fire bad, but the fact its so much worse in its best difficulty, assisted difficulty, in my minimalist pistol focused run compared to the other guns (I've already subtantially tested HG/S9 so they're not even being used in this run, exclusive full testing of Punisher/Red9/Blacktail) and it simply doesn't compare to Blacktail, HG, S9. Its not even close. Punisher is, surprisingly, performing much worse than I would like, too, as its core value is simply proving to be far less efficient at what it is designed for (even on assisted) vs using a sniper for the same role on professional... still the Punisher is clearly better than Red 9.
Also OP, HG was best in OG just a heads up due to its crit factor being more efficient but also because it gave boosted crits to all types of melee attacks. Red 9 was next behind it.
lol
Blacktail is very good, overall, though so really any of those three would do great. I tried to test the pistols before and for human only, not plaga transformed kills, this and the crit guns were too close to matter but due to the adaptive difficulty actually influencing enemy hp as well as even crit chance (yup, its a thing) I gave up testing as it would be to much of a chore to figure out where they truly placed (if not for adaptive difficulty clearly reducing crit chance after several tests then S9/HG came out clearly ahead even on humans but that isn't relevant over the extended course of the game if it isn't always the same... while plaga their hp gets so high it actually does benefit regardless of adaptive difficulty's influence on crit reducing). Then again, an argument could be made that if you spawn a plaga why not just use a sniper / shotgun so this further narrows the gap of Blacktail vs the two crit guns.
I don't use Matilda at all as I feel its particular role is better filled by other weapons but that doesn't mean its bad but not a gun I'd honestly recommend in the pistol class, personally.
Punisher is honestly just completely outperformed by either of the two sniper rifles for the same rule but snipers have better ammo economy by comparison since even on pro it takes 1 (stingray sometimes 2) sniper rounds vs a load of pistol rounds whether its plaga / trash mob lined up multi-headshots or wooden shield enemies.
Short version:
Sentinel 9 / Handgun / Blacktail perform almost identical, though Blacktail has no laser sight so you will want to use it at a bit closer range to offset this fact though its range is still good.
Overall, I think pistols in pro is ass in general, so I'm more basing this on if you plan on using a pistol for ~80%+ of your playthrough.