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The machine has a different pool of charms for each set of tokens (the 4 possible "sets" being GGG, SGG, SSG or SSS). In other words the charms you get using 3 gold tokens will be different from those you get from spending 2 golds and a silver.
Here's a video if you need more information than that:
https://www.youtube.com/watch?v=x7lZsWy4mPM
First, most charms are honestly kind of irrelevant even the infamous striker that makes you run faster isn't that huge of a deal tbh. The most notable one is, honestly, probably Ashley's charm because it makes green herbs far more potent (it does not work on any mixtures though just a heads up).
Second, charms are literally irrelevant on speedruns that require a fresh NG unless you get stupid levels of lucky RNG. S+ requires a NG run, no NG+, otherwise best rating is S.
Third, if you want specific charms just for the sake of having certain charms or all charms in general the optimal way is to NOT spend your tokens. You will want to accumulate as many as you can over 3-4 playthroughs then use the above guide Xaelon posted. This is because token's tree spread is not inherently fair. You aren't going to get a certain combo that eventually leads to Striker or Ashley, etc. You can be completely screwed and go through hundreds of charms and get none of the ones you want if unlucky depending on the seed determined at the start of your NG. Thus you want to have as many saved up to manipulate it as much as possible in a big token spending spree. Preferably, save your game at the end of a run so you can reload and beat up to the first token machine if you get ultra pathetic charm seed because otherwise even 3-4 playthroughs of saved tokens can legitimately deny you a token you want even with that much effort (i've done just that and had to actually move to a 5th NG+ just to get the Striker charm and I had the bonus ones from the treasure map and spent extra spindle on lots of tokens).
Or simply ignore the charm system and take what you get but move on. They're really a poorly implemented system to begin with and marginal benefits.
These are heavy crutches you never should get used to. After I got all the charms.. I never used them again since these 2 heavily trivilize certain encounters. You either mod them in for all playthroughs since they are so nice to have.. or you just stay vanilla for the rawest experience.
If you are at the point where you want to manipulate the gacha.. seriously.. dont waste your time like many of us did. Use the mod. It's the same end result just without wasting tons of time fishing for damn charms.
Not a huge deal to go through repeatedly NG+s just to farm it becuase at that point you will have upgraded almost all the guns already anyways. If you get it much earlier by pure luck though? Sure.
The more movement speed is only 8% which is almost nothing and it is virtually impossibly impractical to get in a speedrun, the only time that extra time cutting benefit would particularly matter. It doesn't make almost any difference in combat or boss fights even for avoiding dmg.
I agree with Tyres' comment that it is probably more ideal to just mod then manipulate the gacha otherwise, as I said, even if you saved all the tokens including bonus tokens from treasure map DLC and bought from store with spare spindle it could still take like 200-300 tokens to get even a single striker charm intentionally and such and you probably will still be missing a number of charms regardless. It is just an impractical pain in the butt and you don't really get enough out of it to justify it.
Some do have nice bonus (the Luis and bettle ones are godly for selling weapons and medicine), but they are really not necessary as a whole.