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any form damage will increase the plague guys passive to give you 1 additional attack to you per turn, so it builds up rather quick. if you hit them 4 times without killing them, they are dealing RAMPING 5 damage per turn, so each turn they are kept alive from this point on will ascend to 5 -> 9 -> 13 -> 17 (increments of 4 instead of 5 because one stack of poison gets removed per turn) damage per turn until the end of battle.
Really, thank god they didn't put poison and thorns in d0 because if you don't understand the order of operations you'd die without understanding anything about why you died.
If I remember right, poison bypasses block since you lose block before poison triggers, so it feels like between that and the petty enemies it's the only thing that messes with the block meta. Unfortunately thorns messes with anything that doesn't rely on block.
Thorns does bypass block, usually. Anything that deals damage or grants block outside the normal order needs to be considered, such as flash dice and barrier (can grant block soon enough to protect you), damage dealing relics (I think most of them are after block but I'm not sure; there's also some that occur before you even finish placing dice), and poison (if you somehow manage to poison them without attacking them, that would consume thorns after block).
The thing that bothers me is that taking damage from the thorns on the petty enemy does not seem to count as them dealing damage to you, for the purpose of petty. That just seems wildly unfair, what's the point of putting both those effects on the same enemy if it's not going to count.