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For seething sigh,
GR: Moves - Pick 2 face, thrown dagger
Trinket - some dmg trinket, stress or dire res.
HW: Moves - Pistol + Wicked
Trinket - some dmg trinket, stress or dire res.
MAA: Moves - Crush, defender
Trinket - stress or fire res
PD: Moves - Nox blast, plague gren, medicine, indisc science
Trinket - stress or fire res
For items, anything that can deal with blind, fire or stress.
All wanderers should be good enough, though PD Alchemist and HWM Yellowhand paths are often better given their R4 and R2 positioning respectively.
For Seething Sigh, I would go with PD Alchemist - GR Deadeye/wanderer, HWM anything but Sharpshot - MAA wanderer. The following tactics should prevent any Sundering Exhalations:
deflating Back Lung (9 HP):
- HWM Pistol Shot (must not be in R1)
- GR Thrown Dagger
- PD Plague Grenade (when you think you'll need just an extra 2-3 HP)
deflating Front Lung (12 HP):
- HWM Wicked Slice
- HWM Duelist Advance (in the event HWM ends up behind R2)
- GR Pick to the Face
- PD Incision (when GR gets shuffled to R4)
- MAA Hold the Line
- MAA Crush (when in R1)
When not on lung duty:
- GR Poison Dart or Pick to the Face on boss
- GR Repartee or Absinthe or move out of R4 as needed
- PD Noxious Blast on boss (the bread & butter damage in this fight)
- PD heals as needed (try to bring consumables for heals instead though)
- HWM Wicked Slice on boss
- HWM Duelist Advance or Take Aim as needed (try to bring Milk soaked linen blind heals instead though)
- MAA Stand Fast or Retribution
- MAA Defender as needed for protection and/or heal setup with Indiscriminate Science
- MAA stress heal or Hold the Line as needed
Skills:
PD: Noxious Blast+, Plague Grenade, Incision, both heals
GR: Pick to the Face, Thrown Dagger+, Poison Dart+, Absinthe, Repartee+
HWM: Wicked Slice+, Pistol Shot+, Duelist Advance, and 2 of 3 between Take Aim, Grapeshot Blast, Open Vein
MAA: Bolster+, Hold the Line, Crush, and 2 of 3 between Defender, Retribution, and Stand Fast.
EDIT: for Deep Breaths, ideally split GR and HWM for front and back damage, having MAA assist in front and PD assist with Plague Grenade in rear as needed. If anyone is blinded though, just focus on one lung and boss.
I tried swapping some other characters in and it went even worse, so will go back to trying with Unusual Suspects again.
I think my problem was not setting up MAA and GR properly for the fight.