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Naturally you may have a better or worse time depending on whether or not you use an optimal Perk setup with your helium using e.g. Perky[grimy.github.io]
For Domination, in my experience it only started to outdo Corrupted in He/hr at around maybe 1B Helium, because I needed to farm a bit to complete it before reaching those 1B Helium. It is however a helpful challenge for unlocking lower cell stuff in the spire.
Another question. At what point does it make sense to use Ethereal heirlooms? The cost to swap stats is crazy high compared to Magnificent quality (2500 compared to 900). Other than the higher base stat rolls I don't really see much of an improvement (at least not one that warrants 3x higher cost to swap variables).