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I think I was progressing rather slow around Zone 140-200.
I wasn´t that active though, so maybe that explains something, and I also don´t remember what my strategy was in regards to when to do C^2s, only that I pushed all normal ones to Z200 before progressing in the Spire.
However maybe I am just doing longer runs compared to you (mostly 1-2 days), because with currently 11,5M Helium and currently no C^2s done yet
(I plan on doing the first round of C^2 runs when unlocking Toxicity at Z 165, which is an absolutely brutal challenge, but with an reward of up to x16,25 Helium for your last Zones and ideally also your Void Maps.),
I have a highest Zone of 151, and completed Mapology and 2 Nom Runs already, so you should be able to do so too.
Altough rerunning Crushed or even Life might still give higher Helium per hour than Nom due to being much faster. 60k (with Nom) is my Top He/hr so far.
Do you spend a lot of Helium in Coordinated?
Because you should spend half or maybe even more in that perk. Each Level gives you an extra Coordination every ~60 Zones I think.
So that´s basically 2 to 2,5 Coordinations per Coordinated Level at your point, compared to Carpentry (which was previously the most important perk) only giving about 0,5 Coordinations per Level (although also extra Resources from Jobs and Loot)
That aside I don't remember any real slow down until I was in the late 400 early 500.
I remember that I was done with Life (that I hated from the depths of my heart) in less than two days and from there moved to next challenges, never spending more than a few days repeating the same.
I finished the progression from ~130 to having finished the zone 150 Mapology challenge in one day. Guess I underestimated the idling part of the game - just take a look every few hours to run maps (which can be automated later I believe) and upgrade Gigastations.
If repeating the challenges every few days is the game I have to go with it.
If you can, run a Z150 Void Map, which unlocks "Map at Zone".
Although if you´re running Nom and complete Void Maps on Z145 for the Helium
(although it will take you quite a bit of farming for metal, you need all or almost all weapon prestiges depending on progress),
you should probably only sacrifice a Deadly type Void Map for this
(those are very hard or impossible at Z145 Nom, depending on progress, due to Attacking first in Spite of Nom)
Map at Zone basically allows you to automate a lot of the earlygame.
Buildings and Geneticists are the only parts left you have to manage yourself at that point, those will unlock at Z170 and 180 I think.
I went with Map at Zones 12 and 15, create a (rather low cost) Map, Repeat for all Items, Exit to World, and repeat both every 10 Zones.
Also Map At Zone 145 Cell 90, so I don´t accidentally complete Nom if I want to do Nom Void Maps.
You do still have to run Unique Maps (like Wall and Dimension of Anger) manually though.