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You need two automatic weapons with as big of a magazine as you can find. Rifle + Rifle, or Rifle + SMG (ideally 60 round stuff) should be enough, at least it was for me. I switch guns instead of reloading.
Nowadays I just use PRK 16 with 95 round magazine. It has enough ammo to kill all the ghouls, blast the nest, and have 1/4 of the magazine still left.
Not quite – ghouls used to spawn several smaller waves in earlier game versions. I also talked about that in the post linked above.
It's absolutely possible to do it with a single 30-round mag of an AR.
I haven't tried it with the weaker ones (EC 74 & EC 74U), but by the time I'm dealing with infestations, I'm either using an ECM or a ZZ Vel. It's tight, but one mag is definitely enough to take out a wave.
They tend to come at you in a line. Aggro the infestation from range with a single shot, take out the ghouls as they come out and rush after you.
Or better yet, situation allowing, take it out with a sniper from max range. That won't trigger a wave.
The big problem, as I mentioned in the thread BlueSpark linked to, is when the infestation is positioned in such a way that you can't see/shoot it unless you get really close.