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You can also just give her poison medicine for poison and fire seems to go down in increments of 3 if you go into water. Clinic is total overkill for this. Given enough time these are ailments the average human npc can and will walk off.
https://steamcommunity.com/sharedfiles/filedetails/?id=3158386848
Just use Assist > Cure to try to fix their ailments.
Golden Acupuncture helps by making it so that when you hit a node, it cures all the ailments directly around it.
But it's not always necessary.
You have to cover ALL the injury-nodes though, otherwise nothing happens.
Note: the AI's still really finicky. Sometimes they won't do this, sometimes they will. Best to make a backup save so that if your wife doesn't take the pills, you can just reload to before you gave her the pills. That way you won't waste them, at the very least.