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I presume you don't have any controller plugged-in nor any other devices that might interfere/conflict (plug them out if you have any).
Turn off any 3rd party overlay (STEAM or nvidia). Also wireless mouse can be at odds at time, test a wired ones if you have.
Check as well your os Control Panel and then Mouse Setting.
Edit: some more suggestions
https://guides.magicgameworld.com/hitman-3-keyboard-mouse-not-working-issue-fix/