How do you get rid of the "Ignorant" effect?

[Germanistan]

You know, the curse you get when you die. Is there an option to remove it?

[Mamluk's Honor]

Find or buy a purple potion to remove it.

Or pick cats luck so when you die you don't get it.

Or equip a coin so you don't get it.

[CHOO CHOO]

Talk to the totem, it'll give you a mini-quest that'll remove the curse once completed. Only works on full curses though, meaning only once you died thrice.

[OsaX Nymloth]

Curses and Flaws of Soul can be removed via Purple Revival potion.
Curses can be also removed by Totem of Soul - talk to it and you will receive a special quest.

Flaws of Soul alone are more of a reminded to be careful and that a full blown curse is just waiting around the corner - but in itself, Flaws are not that dangerous. Curses tho, are of course different kind of problem and getting rid of them fast is a good idea.
Or use one of the protection items to reduce the risk!

[CHOO CHOO]

Yeah, since most of the blessings aren't very useful, or at least not necessary, it's generally a good idea to spend a coin on getting the totem to give you the Cat's Luck, so you don't acquire flaws and curses on dying.

[Germanistan]

Thanks, everyone