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As a general clue, read any litterature you can find, and look for more books to read.
As for those doors in the Inner Sanctum, you'll find the hint that points you towards figuring that out after making it back to room 46.
I'll say that the Library links to a unique room only reachable from it. I recommend saving a bunch of reroll die up if you see a library so that you can try and force it. I don't know if there is anywhere in the game that tells you about it, so giving this to you outright. You'll most likely need to come back here over 2-3 runs at least.
Finally, the one lab experiement that sends mail to the mail room is quite helpful. It will give you a lot of hints about various things.