Invented nicotine, but the triumph was short-lived: had to switch to an iron horse

[Blueberry Muffins!]

Most of the demonic descriptions seem self-contained or at least paint a comprehensible picture. This? This seems to imply some kind of reasoning, . . . what? Is the iron horse an allusion to the entire industrial revolution, and the pollution it brought? . . . okay, that kinda makes sense to me now.

[TomasVaner]

There is a saying "A drop of nicotine can kill a horse". Do this description alludes to this phrase. They invented nicotine and it killed their horse