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A longer run to raise holy arch helps with the milestones (try at least 250, 300 would definitely be enough).
When I used auto-reincarnation for the first time, I afaik had ~200 heartstones and at least 250 hidden mission milestones (maybe 300, not sure about it now).
Keep in mind that I just tried auto reincarnation at some point and iI had already over 5e20 dps by area 5-4. The ~200 heartstones were an overkill (100 would have been more than enough).
And obviously I assume you use all S-rank gear with all Road 1 and 2's completed 5 times.