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I tested it with mana regen rune in a shield and it worked for my friend.
If you are in a shared co op, they can use runes. To test if you are in a shared co op or not, see if they are getting the sanguinax healing item upgrades. If your guest can upgrade their healing item, they can also use runes. If they can not upgrade their healing item, they also can not use runes.
I haven't personally tested this information, this is just what I found on Reddit.