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before I will try to suggest something, is following some guide about ascension good for you?
Me personally, I am following an ascension guide that helped me.
If you would like to at least check that ascension guide along with Permanent slot guide, it's all in one place, you just need to read it. I don't think that copying the text and pasting it here is very usefull so I will leave a link here to that guide and you can decide if you want to follow it or not. Read carefully especially the Permanent slot part :)
Guide:
https://steamcommunity.com/sharedfiles/filedetails/?id=2591077269
But once you have ascended 10+ times and have 200+ hours of gameplay you can probably consider waiting a bit more time to ascend as you won't benefit as much from ascending once you get into the late game, as there's fewer good heavenly upgrades left, and takes longer to ascend especially after 9 quadrillion prestige level, because something to do with javascript limitations with big numbers.