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During a Frenzy they accumulate cookies 7x faster, so it's better to wait until the frenzy finish if you intend to pop then.
You will always get more cookies than you "lost" to wrinklers. So let them feast as long as you like.
No.
Theoretically the best way to "use" wrinklers is to wait until they are maxed out(10 or 12, if you bought "Elder Spice" in the upgrade tree) then wait until they accumulated enough cookies to buy your next upgrade, then put Skruuia in the temple's diamond slot and just then pop all twelve.
Personally, I never found Wrinklers to be worth all the hassle. The amount of cookies they reward is REALLY insignificant in comparison to just doing a Frenzy+Click Frenzy Combo.
I use them only to get eggs from Easter Season and special cookies from Halloween Season.
https://cookieclicker.fandom.com/wiki/Wrinkler